EFFECT OF UREA ON TOPICAL ABSORPTION OF DICLOFENAC DIETHYLAMINE THROUGH HAIRLESS RABBIT SKIN

Abstract

In the present study, the effect of Urea as an enhancer on transdermal absorption of 1% Diclofenac Diethylamine (Non-steroidal Antiinflammatory Drug) through hairless rabbit skin was evaluated in-vitro study at various concentrations to improve the skin permeability. From the data, Urea shows slightly large lag time gives a picture about its enhancing effect. The permeability rate constant is almost approaching to 1 in almost all the concentrations of urea. The permeability co-efficient of Diclofenac Diethylamine did not change under the influence of urea at concentration 0.1, 0.2 and 0.3% but it was increased by increasing the concentration of urea.