IN-VITRO STUDY OF PERCUTANEOUS ABSORPTION OF DICLOFENAC IN THE PRESENCE OF SODIUM LAURYL SULPHATE THROUGH RABBIT SKIN

Abstract

In the present study, effect of various concentrations of Sodium Lauryl Sulphate (SLS) as an enhancer on transdermal absorption of Diclofenac diethylamine through hairless rabbit skin was evaluated in-vitro. From the data, SLS shows that the smallest lag time gives a picture about its rapid enhancing effect. The permeability co-efficient and flux rate calculated for Diclofenac in the presence of SLS as an enhancer shows that the penetration of drug through hairless rabbit skin has been significantly increased.